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What is Darunaj - Doronicum hookeri:
Doronicum Hookeri normally recognized as "Darunaj-aqrabi/Daroonaj-aqrabi" in USM and as "Leopard's bane" in English is a famous medicinal plant of own circle of relatives Asteraceae. It is shipped among 12,000 and 14,000 toes withinside the Himalayas at Lachen and Tungu, Sikkim, Nepal, Bhutan and Tibet . Rhizomes of Doronicum roylei DC. (Native to Punjab), Doronicum falconeri Hook. Darunaj-aqrabi is one of the important plant origin pills, widely used in exclusive dosage sorts of Unani Medicines. It is dried rhizomes of Doronicum hookeri.
Darunaj-aqrabi (Doronicum hookeri C.B. Clarke ex Hook.f.) (Family Asteraceae) has lengthy been utilized in Unani device of medicine (USM) as Cardiac tonic (invigorative and exhilarant), nervine tonic, carminative, shielding of the foetus, antidotary etc. in exclusive dosage forms. It is blanketed in particular pills for coronary heart and is a whole lot precious for palpitation. Because of getting antidotal traits and shielding (corrective) attributes, the rhizomes are normally utilized in compound formulations having tonic outcomes for the body. Aim of the evaluate: The examine pursuits to mirror the significance of Darunaj-aqrabi in USM. This evaluate presents important statistics that specialize in conventional use, phytochemistry, and pharmacological profile, thereby figuring out studies gaps and destiny possibilities for research and improvement of this plant. Materials and methods: All to be had facts associated with Darunaj-aqrabi withinside the the world over generic medical databases such as Pub Med, Science Direct, Scopus, Sci Finder, Google Scholar, Microsoft academy and Web of Science had been searched. Additional facts became accumulated from the classical textual content of USM on Herbs, Unani Pharmacopoeia, and so on. Results: The literature supported its use historically in formularies or with the aid of using rural human beings as a digestive, carminative, shielding of the foetus, cardiotonic, belly tonic, liver tonic, lithotriptic, antidote etc. Its extract confirmed antibacterial, antifungal, hepatoprotective, and antioxidant hobby. The primary phytochemical components are alkaloids; saponins; flavonoids, photoactive thiophenes, sesquiterpene alcohol, paralianchol and its acetophenone derivatives. There is restricted statistics to be had in this plant. Conclusion: The modern pharmacological research confirmed the anti-microbial, antifungal, hepatoprotective, and antioxidant hobby of Darunaj-aqrabi. However, maximum of the components of this herb have nonetheless now no longer been identified. Along with this, there are insufficient information at the phytochemistry and toxicological profile. Due to the substantial conventional makes use of of Darunaj-aqrabi, greater studies on pharmacological activities, phytochemistry, toxicity and unfavourable outcomes have a tendency to be required to decide its medicinal values.
It is used in the treatment of Zo’f-ī-Qalb (weakness of the coronary heart), Khafqān Bārid (palpitation because of cold), Tā’un (plague), Fālij (hemiplegia), Laqwā (Bell’s palsy), Melancholia (depression), Nafakh-ī-Shikam (flatulence), Waja al-Mi’da (abdominal pain), Dard Rahim Rehi (uterine pain due to
accumulation of gasses), Uterine flatulence, Insomnia, Riyah al-Afrisa (displacement of vertebral column), Awram Batina (superficial inflammation) and snake and scorpion bite . Eating it together with figs is effective in all kinds of poisons, snake and scorpion bites . It attenuates (talteef) and dissolves (tahleel) intestinal inflammation . Using it with sugar is beneficial in phlegmatic headache and chest pain . It strengthens the coronary heart and proves to be beneficial in palpitation . Due to its antidote properties, it's miles being utilized in epidemic illnesses especially in plague
In an in vitro study, Streptococcus faecalis have been cultivated in nutrient agar media with the addition of a mixture of Dichloromethane and methanol extract of Doronicum hookeri in different concentrations. The boom of the micro organism changed into inhibited in 500 μg/ ml concentrations of the extract displaying its
antibacterial activity. Streptococcus faecalis, also known as Enterococcus faecalis, is the main pathogen of the genus Enterococcus which causes around 95% of enterococcal infections, which include infections of the urinary tract, infections of the biliary tract, ulcers (e.g., bed sores), wounds (especially
abdominal) and occasionally endocarditis or meningitis. It is a normal vaginal commensal and intestinal tract.
Bioactive chemicals obtained from natural sources such as plants may be a potential supply of antifungal, specifically withinside the present
state of affairs in which resistance to antifungal agents has been followed via way of means of human and plant-parasitic pathogens. Doronicum hookeri has shown promising in vitro antifungal activity. Dichloromethane and methanol extract of Doronicum hookeri rhizome changed into evaluatedtowards Saccharomyces cerevisiae and Candida albicans at concentrations of one thousand and 500 μg/ ml in the nutrient agar medium which
proven robust antifungal activity.
Doronicum hookeri has been said for its antifungal, Antimicrobial hobby, antioxidant and hepatoprotective activities . Recently cardioprotective, antiatherogenic and lowering outcomes of blood pressure
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